Unmet Need
Hemorrhage
Hemorrhage is a Leading Cause of Preventable Death1
Trauma is the
#1
cause of death
in adults <45 years old2
Of trauma deaths
~40%
from hemorrhage2
Hours until death
~1.6
from exsanguination*3,10
Hemorrhage increases mortality in:
Trauma4,5
Cardiac Surgery6
Childbirth7
Combat8,9
Fibrinogen
Fibrinogen decreases rapidly and significantly in hemorrhage5,11
Fibrinogen level in the low 200’s is an independent risk factor for severe hemorrhage in post-partum hemorrhage,12 cardiac surgery,13 and trauma.14
INTERCEPT® Fibrinogen Complex is now available for control of bleeding, including massive hemorrhage, associated with fibrinogen deficiency
Learn more about INTERCEPT Fibrinogen Complex’s role in hemostasis
You May Also Be Interested In
INTERCEPT FIBRINOGEN COMPLEX: Ready When You Are. INTERCEPT Fibrinogen Complex is a pathogen reduced, fibrinogen enriched, blood component for transfusion providing you with an immediate source of key factors known to be important in effective hemostasis.
PATHOGEN REDUCTION: Be Ready. Reduce the risk of transfusion transmitted infections by using blood products treated with the INTERCEPT Blood System Pathogen Reduction System.
CLOT GENERATION: Successfully regaining hemostasis during hemorrhage requires a complex balance of factors involved in clot initiation and construction.
*Severe loss of blood
References
1. Drake SA, Holcomb JB, Yang Y, et al. Establishing a Regional Trauma Preventable/Potentially Preventable Death Rate. Annals of surgery 2018. 2. Callcut RA, Kornblith LZ, Conroy AS, et al. The why and how our trauma patients die: A prospective Multicenter Western Trauma Association study. The journal of trauma and acute care surgery 2019;86:864-70. 3. Cripps MW, Kutcher ME, Daley A, et al. Cause and timing of death in massively transfused trauma patients. The journal of trauma and acute care surgery 2013;75:S255-62. 4. Stanworth SJ, Davenport R, Curry N, et al. Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice. The British journal of surgery 2016;103:357-65. 5. Rourke C, Curry N, Khan S, et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. Journal of thrombosis and haemostasis. JTH 2012;10:1342-51. 6. Görlinger K, Shore-Lesserson L, Dirkmann D, Hanke AA, Rahe-Meyer N, Tanaka KA. Management of hemorrhage in cardiothoracic surgery. J Cardiothorac Vasc Anesth 2013;27:S20-34. 7. Butwick AJ, Goodnough LT. Transfusion and coagulation management in major obstetric hemorrhage. Current opinion in anaesthesiology 2015;28:275-84. 8. Stinger HK, Spinella PC, Perkins JG, et al. J Trauma. 2008;64:S79-S85; 9. Joint Trauma System, Damage Control Resuscitation Clinical Practice Guideline, 12 July 2019. 10. Fox EE, Holcomb JB, Wade CE, Bulger EM, Tilley BC. Earlier Endpoints are Required for Hemorrhagic Shock Trials Among Severely Injured Patients. Shock 2017;47:567-73. 11. Hiippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesthesia and analgesia 1995;81:360-5. 12. Charbit B, Mandelbrot L, Samain E, et al. The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. Journal of thrombosis and haemostasis : JTH 2007;5:266-73. 13. Ranucci M, Pistuddi V, Baryshnikova E, Colella D, Bianchi P. Fibrinogen Levels After Cardiac Surgical Procedures: Association With Postoperative Bleeding, Trigger Values, and Target Values. The Annals of Thoracic Surgery 2016;102:78-85. 14. Hagemo JS, Stanworth S, Juffermans NP, et al. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study. Critical care 2014;18:R52.