Clot Generation

Successfully regaining hemostasis during hemorrhage requires a complex balance of factors involved in clot initiation and construction.

Successfully regaining hemostasis during a hemorrhage requires a complex balance of clot initiation and construction.

Clot Initiation:

Factors important to clot initiation, such as tissue factor, von Willebrand Factor (vWF), factor VII and thrombin, are abundant in early hemorrhage.1,2 Platelets bind to the injured endothelial cell wall via vWF to initiate clot formation. Thrombin cleaves fibrinogen to make fibrin for clot mesh construction.3

Healthy Clot Construction

A strong, stable clot includes a tight fibrin mesh with platelet aggregates and entrapped red blood cells.

Fibrin creates a mesh around red blood cells and platelets, covering the vessel injury. Activated factor XIII connects and interlaces the fibrin strands, strengthening the clot and providing resistance to plasmin mediated degradation.3

Fibrinogen, factor XIII and von Willebrand factor add the clotting strength needed to achieve stable clot formation and restore hemostasis.

Diagram of components of a healthy blood clot

Weak Clot Pathology

Trauma and hemorrhage can lower clot strength and increase clot fragility.

In traumatic hemorrhage, fibrinogen, factor XIII,3,4 and platelets are depleted rapidly by a combination of use and plasmin degradation.5

Without fibrinogen binding platelets together and fibrin crosslinked by factor XIII, platelets are unable to contract the clot.

Reduced availability for these factors results in:

  • Loose clot formation
  • Failure to cover vessel injury
  • Rapid clot degradation
Diagram of a weak blood clot

INTERCEPT® Fibrinogen Complex

INTERCEPT® Fibrinogen Complex is an enriched source of fibrinogen and factor XIII, which are rapidly depleted in hemorrhage.6

Replenishing these key components is important to stable clot formation and hemostasis.2,7