What's in the Bag?

When Minutes Matter.
INTERCEPT® Fibrinogen Complex is an enriched source of key constituents in effective hemostasis for the treatment and control of hemorrhage associated with fibrinogen deficiency.

INTERCEPT® Fibrinogen Complex is a pathogen reduced cryoprecipitated fibrinogen complex derived from the cryoprecipitation* of human plasma.

INTERCEPT Fibrinogen Complex is produced from the INTERCEPT Blood System for Cryoprecipitation to make an enriched source of key constituents in effective hemostasis1-3:

  • Fibrinogen
  • Factor XIII
  • Von Willebrand Factor

Functional levels of these key constituents correlate with the risk of bleeding, morbidity and mortality.4-6

Healthy Clot:

Platelets and red blood cells are tightly bound to the vessel wall and each other by fibrinogen, fibrin, factor XIII, and von Willebrand factor, key constituents of hemostasis7

Fibrinogen, Factor XIII and von Willebrand factor add the clotting strength needed to achieve stable clot formation and restore hemostasis.

The INTERCEPT Blood System provides broad spectrum pathogen reduction of the plasma used to derive the INTERCEPT Fibrinogen Complex allowing it to be stored transfusion ready, at room temperature, post-thaw, for up to 5 days.8

INTERCEPT Fibrinogen Complex retains in vitro functional characteristics 5 days post-thaw.8

FC15 Characteristics Result at Thaw Result at 5 days Post-Thaw

Volume
(mL)

147 ± 7
[136 – 155]
Not measured

Fibrinogen content
(mg)

1556 ± 248
[1209 – 1913]
1435 ± 206
[1129 – 1760]

Factor VIII content
(IU)

407 ± 78
[333 – 567]
367 ± 78
[276 – 518]

Factor XIII antigen
(mg)

17.2 ± 3.3
[13.6 – 24.3]
16.0 ± 2.2
[12.4 – 18.8]

vWF ristocetin
cofactor
activity
(IU)

720 ± 210
[423 – 977]
702 ± 215
[399 – 961]
vWF Antigen
(IU)
979 ± 132
[848 – 1269]
985 ± 147
[869 – 1327]

Mean ± Standard Deviation (SD) [range], n = 8
#INTERCEPT Fibrinogen Complex sample was derived from 4 whole blood-derived plasma inputs